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导 读：枸硫酸西地那非片 。
它好像既不足安全性，也不足合理。
性领域的“苦衷”，不但男士会出现，一些女士一样会出现。
听说，光英国就会有六百万女士身患“甲状腺机能亢的性欲障碍”（hypoactive sexual desire disorder，通称HSDD）——很多女性朋友们对“性”提不起来兴趣爱好，又或者在亲热中情况较差，立即影响到了生活品质。(\"About six million U.S. women experience HSDD, but few women receive treatment for the condition,\" - Reuters)
(图via Getty)为了更好地改进众多女性朋友的勃起功能障碍难题，近期，英国就发布了一款药物：这款名字叫做\"Vyleesi\"（唯乐思）的药，便是用于提升女性性欲的。别名“女版伟哥”。
▲Vyleesi (图via AP)上一个月，“翘首以待始出去”的唯乐思，总算被英国食品药品管理处给准许了……
The U.S. Food and Drug Administration approved Vyleesi (bremelanotide) to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.英国食药监管理处准许了唯乐思（关键成遍布美诺肽），用于医治绝经前女性的甲状腺机能亢的性欲障碍。“There are women who, for no known reason, have reduced sexual desire that causes marked distress, and who can benefit from safe and effective pharmacologic treatment. Today’s approval provides women with another treatment option for this condition,” said Hylton V. Joffe, M.D., c, director of the Center for Drug Evaluation and Research’s Division of Bone, Reproductive and Urologic Products. “一些女人在沒有其他已经知道缘故的情形下，性欲下降并引起了显著的痛楚。他们能够从安全性合理的用药治疗中获益，改进现况。”博士、英国骨质增生、生殖系统和泌尿男科药品评定和研究所许多人Hylton V. Joffe说。“As part of the FDA’s commitment to protect and advance the health of women, we’ll continue to support the development of safe and effective treatments for female sexual dysfunction.”“食品药品管理处服务承诺维护和推动女人的身心健康。做为这一服务承诺的一部分，大家将再次适用对外开放安全性和合理的女士勃起功能障碍治疗方法。”▲FDA approves new treatment for hypoactive sexual desire disorder in premenopausal women (via fda.gov)
(图via Getty)但是……尽管上边这名专家建议得浇好，还指出了医治药品的“安全性”“合理”，但唯乐思这款药的主要表现，却有一些“抽脸”。由于，它好像既不足安全性，也不足合理。
最先，依据《华盛顿邮报》的观点，唯乐思十分的不便：要在立马要亲热以前才可以应用，并且药品并不是内服，得自身注入到身体。
Patients inject Vyleesi under the skin of the abdomen or thigh at least 45 minutes before anticipated sexual activity. Patients should not use more than one dose within 24 hours or more than eight doses per month.病人需要在预估的性生活产生前最少45分钟，在腹腔或大腿根部的肌肤下注入唯乐思。24小时内应用的摄入量不可以超出一剂，或是每月的应用使用量不可以超出八剂。▲A new \'female Viagra\' approved by FDA despite skepticism (via WP)
▲类似就这样注入的 (图via Getty)
“親愛的的，咱滚床单吗？”“这些，我先扎一针。”——随后往自个肚子上一duang。再等着45分钟。
并且，据美国《卫报》报导，唯乐思不但用的时候不便，还大概率附送了头晕恶心想吐等不良反应……Side effects reported during clinical trials included mild to moderate nausea lasting no more than two hours and mostly occurred over the first three doses, Amag said. About 40% of patients in clinical trials experienced nausea.Amag药业公司表明，在临床研究汇报中，唯乐思的不良反应包含了轻到中重度的、延迟时间不超过两小时的恶心想吐，关键产生在前三次注入期内。在药物临床试验中，约有40%的病人觉得了恶心想吐。▲Vyleesi: latest attempt at \'female Viagra\' approved by US regulators (via The Guardian)除开恶心想吐外，不良反应也有头疼、通红这些。(\"Side effects during the trial included headaches, flushing and nausea.\" - WP)
这还不会啥。更可怜的是，如果你因应用唯乐思遭了这么多罪，它也许还……失灵……
看一下英国食药局的汇报，能够说很无奈了：The effectiveness and safety of Vyleesi were studied in two 24-week, randomized, double-blind, placebo-controlled trials in 1,247 premenopausal women with acquired, generalized HSDD. 对于唯乐思的有效与安全系数，科学研究员工对1247名患性欲衰退的绝经前女士完成了24周的任意、双盲实验、安慰剂对照实验。In these trials, about 25% of patients treated with Vyleesi had an increase of 1.2 or more in their sexual desire score (scored on a range of 1.2 to 6.0, with higher scores indicating greater sexual desire) compared to about 17% of those who took placebo. 在这种实验中，接纳唯乐思医治的病人里，约25%的病人性欲望评分提升了1.2或之上（成绩范畴1.2-6.0中间，评分越高表明性欲望越强）。而接纳安慰剂效应医治的病人中，性欲望提升的占比约为17%。There was no difference between treatment groups in the change from the start of the study to end of the study in the number of satisfying sexual events. 从分析的进行到完毕，唯乐思医治组到达到性事的数目上（与信息组）并沒有显著差别。Vyleesi does not enhance sexual performance.唯乐思并不可以增强性能力。▲FDA approves new treatment for hypoactive sexual desire disorder in premenopausal women (via fda.gov)……因此搞了半天，英国准许这一药有一个锤头用？
但不要说，除开唯乐思以外，英国以前还准许过一个一样称得上“女版伟哥”的药：Addyi（阿迪达斯依）
▲Addyi (图via DIANA ZUCKERMAN)
阿迪达斯依是十五年准许推出的，那时候是国外的第一款医治女性欲低下的药品。和现如今的唯乐思比起來，阿迪达斯依的主要表现就更让人烦透了：它实际效果更比较有限、用起來更不便、不良反应更显著。Addyi was approved under intense pressure from advocacy groups despite a review by scientists at the Food and Drug Administration (FDA) that deemed it minimally effective and possibly unsafe.虽然英国食药局的专家觉得，阿迪达斯依的实际效果几乎为零，并且很有可能不足安全性，但它或是在适用组织的很大的压力下，得到了发售准许。▲Vyleesi: latest attempt at \'female Viagra\' approved by US regulators (via The Guardian)Addyi never really took off, partly because it is a daily pill that takes a while to work, and the product carries a \"black box\" label that warned of serious side effects such as dizziness and low blood pressure when the drug was taken with alcohol.阿迪达斯依从没得到过取得成功。一部分因素就在于它是一种药丸，得每日服食，并且必须一段时间才可以起功效。而且，该药物含有一个“飞机黑匣子”标识，警示与乙醇一起服食会形成比较严重不良反应，如头昏和血压低。（即服食阿迪达斯依就得严苛控酒）▲A new \'female Viagra\' approved by FDA despite skepticism (via WP)
▲伟哥（“伟哥”，右）是深蓝色药丸，阿迪达斯依（左）则是充斥着少女感的粉红色药丸 (图via Lisa Chiu/CGTN)
但是……尽管这种中药不良反应大且没什么进展，但最少女士的“性福生活”能被群众【关心大家请加微信好友：yaodaoyaofang 】，并落落大方地拿出来探讨、找寻解决方法，终究是件好事儿。终究，每10位女士中最少有一个身患HSDD（性欲障碍），更有高达1/3的女生遭受过有关情况的困惑：Conservative estimates say 10 percent of women have HSDD, but some research suggests the condition is under-diagnosed and affects closer to 33 percent of women, says Heather L. Beall, MD, a gynecologist at Northwestern Medicine McHenry Hospital. 大西北医科大麦克风伯特医院门诊的妇科大夫Heather L. Beall博士表明，据保守估计，有10%的女生身患性欲障碍。但一些研究表明，这类疾患的确诊不够，具体危害了近33%的女士。▲1 in 10 Women Has This Sexual Disorder—and Doesn’t Even Know It (via msn.com)
(图via irinamunteanu/Getty)如果是处在或相邻女性更年期、在服食避育药、在服食抗抑郁药、经历在性层面不高兴的历经……这种女士，特别是在有患HSDD的很有可能。Anyway, 期待有这一困惑的姑凉们可以认清难题，早日恢复，有着更开心幸福的日常生活。❤
文：lanlan图：外国媒体、互联网等题图：irinamunteanu/Getty药道网：枸橼酸西地那非片对身子有毒吗
