The Post-Finasteride Syndrome (PFS) is a devastating condition characterized by the persistence and development of diverse sexual, neurological and physical side effects after discontinuation of 5-alpha reductase inhibitors such as finasteride and Dutasteride. Symptoms are variably distributed from person to person, and vary widely in severity. The condition has a life-altering impact on victims and their loved ones, too often leading to career loss, the loss of relationships, and suicide. Its mechanism(s) are currently unclear, and the predispositions that cause a subset of men to develop PFS from as little as a single exposure to a 5-alpha reductase inhibitor remain unknown.
The Post-Finasteride Syndrome can develop after as little as one dose or suddenly after years of taking the drug without prior complaint, with many severe cases having taken the medication for only days. 有些人用一次非那雄胺即可发展后非那雄胺综合征，也有人在用了几年非那雄胺都没事之后突然出现后非那雄胺综合症，有很多特别严重的案例仅仅因为吃了几天的非那雄胺而已。
（2）使用非那雄胺出现严重副作用的后果严重。这种严重后果一般就是我们说的这种长期性的PFS症状。 出现严重副作用不像很多网络上以销售非那雄胺为生的营销者说的那样，停药很快就消失，副作用概率很小，他们这样宣传误导言论无非是为了自己能多挣点钱罢了。 提到这些年发表的关于非那雄胺综合症的论文，比如文献【1】：The Post-finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption（后非那雄胺综合症： 药物引起的内分泌紊乱表观遗传学临床表现） 这篇文章就提到，目前我们既不知道非那雄胺如何导致的这些所谓的永久性综合症，也没有办法治疗这些永久性综合症，这些综合症的出现对很多用非那雄胺治疗脱发的年轻人是一种毁灭性咑撃，甚至导致自杀。
文章说： Psychological symptoms and cognitive dysfunction of PFS are far more serious and difficult to treat than sexual dysfunction symptoms and may lead young men to contemplate, attempt, or even commit suicide.
The medical community has an obligation not to turn a blind eye on this rare yet debilitating condition in young men. Patients with this condition should not be stereotyped or stigmatized by untrained and unprepared clinicians, due to lack of awareness and knowledge pertaining to this new and rare syndrome. Greater awareness and education is needed among the medical and scientific communities in order to develop better approaches for managing men with PFS. 医学界有义务不对这些不常见却使得一些年轻男性衰弱的症状视而不见。而那些患有此症状（后非那雄胺综合症）的男性，不应该被那些不了解这种症状的医护工作者赋予刻板形象或者污名化。需要进一步提到医疗界和学术界对PFS了解，加强教育，从而更好的应对PFS症状。
当然也有文献提到不同意见，比如文献【2】：A comment on the post-finasteride syndrome（关于后非那雄胺综合症的评论）就提到，目前也还不能完全就把后非那雄胺综合症定义为一种疾病，我们对它知之甚少，也有人提到关于后非那雄胺综合症这些年发表的论文全是一些低质量的学术文献，后非那雄胺综合症不仅仅和非那雄胺相关，也应该考虑药物的反安慰剂效应以及停用非那雄胺后的一些病人自身的疾病和心理状态，后非那雄胺综合症需要我们的重视，也需要进一步的研究才能搞清楚。 再比如文献【3】：Post-finasteride syndrome - does it really exist?（后非那雄胺综合症—它真的存在吗？）也在探讨后非那雄胺综合症。 文献说学术上一般这样定义后非那雄胺综合症： Post-finasteride syndrome (PFS) is usually described as the occurrence of persistent adverse events, including sexual dysfunction and depression, in a subset of men that used a 5a-reductase inhibitor. 后非那雄胺综合症（PFS）一般定义为在使用5α还原酶抑制剂的男性中，有一些人出现永久性性功能障碍和焦虑症状的副作用。
【1】Traish A M . The Post-finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption[J]. Current Sexual Health Reports, 2018. 【2】Hudson Rezende,Maria Reis Gavazzoni Dias,Ralph Trueb. A comment on the post-finasteride syndrome[J]. International Journal of Trichology,2018,10(6). 【3】Radosław B. Maksym, Kajdy A , Michał Rabijewski. Post-finasteride syndrome – does it really exist?[J].
